Understanding

Tissue Structure

The TEAM Hub draws on different disciplines and perspectives to investigate the role of the tissue microenvironment in disease

Illustration of cells.
A scientist examines cells through a microscope.
Illustration of cells.
Illustration of cells.

We need better tools

to identify changes in biological tissues associated with disease before there is a significant disruption of tissue structure and function. We also need to streamline the development and testing of new therapeutics that can prevent or reverse tissue damage in chronic incurable diseases. The TEAM Hub is constructing a biologically inspired pipeline to generate a dynamic picture of the tissue microenvironment. Combining imaging approaches and 3D artificial tissue models, we investigate the effects of tissue structure on cellular functions, the mechanisms underlying changes in tissues and healing processes, and the factors that affect the body’s response to injuries and diseases.

Core Research Members

The TEAM Hub is composed of experts from diverse areas, ranging from Health Sciences to Physics and from Engineering to Biology. Meet the team behind this ambitious research.

Dr. Leila Mostaco Guidolin

Dr. Leila Mostaço-Guidolin

PhD, PEng
Co-director​, Topic Lead Tissue Microstructure

Dr. Adana Cassol

Dr. Edana Cassol

PhD
Co-director, Topic Lead Cell Biology

Dr. Adam Shuhendler.

Dr. Adam Shuhendler

PhD, CRC-T2 in Chemical Biology
Topic Lead Biophotonics and Image analysis

Dr. Andrew Harris.

Dr. Andrew Harris

PhD
Topic Lead Tissue Microstructure

Dr. Barbara Vanderhyden

Dr. Barbara Vanderhyden

PhD
Topic Lead Disease Biology

Dr. Emilo l. Alarcon.

Dr. Emilio I. Alarcón

PhD
Topic Lead Disease Biology

Dr. Jeffrey Smith

Dr. Jeffrey Smith

PhD
Topic Lead Biochemistry

Dr. Joerg Overhage

Dr. Joerg Overhage

PhD
Topic Lead Cell Biology

Dr. Menno Oudhoff

Dr. Menno Oudhoff

PhD

Dr. Sangeeta Murugkar

Dr. Sangeeta Murugkar

PhD
Topic Lead Biophotonics and Image analysis

Dr. William Willmore

Dr. William Willmore

PhD
Topic Lead Biochemistry

Bioprinter close up

Research Areas

Check below for details about all research conducted within the TEAM Hub.

FACILITIES

TEAM Hub Research Nodes

Check below for details about all research conducted within the TEAM Hub.

The Next Generation Of Experts

By providing research opportunities and developing educational programs for the larger community, we are helping Ontario and, indeed, all of Canada build expertise in emerging but increasingly important areas of research.

Latest News & Publications

Il-13 -driven-tuft-cell-hyperplasia.
Publication

BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia

Although Helminth infections are prevalent throughout the world, they are particular a health...

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Intestinal epithelium cells close-up.
Publication

LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium

After birth, the epithelium that lines our gut transitions (or matures) so that it can deal...

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Publication

Targeting mRNA binding proteins to respond to stress responses

The paper establishes the phosphorylation of heterogeneous nuclear ribonucleoprotein A1...

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Partners

Interested in collaborating, partnering with us or learning more about our facilities?