Dr. Jeffrey Smith
Credentials:
PhD
Position:
Topic Lead Biochemistry
Research Area(s):
Biochemistry
Institution:
Carleton University
Expertise:
Mass Spectroscopy, Lipids
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Research
Areas
Breaking Knowledge Barriers Through Transdisciplinary Research
By integrating experts from different fields, the TEAM Hub is able to undertake unique and interdisciplinary research. Engineers and biologists work side by side, and health scientists and cell biologists collaborate with physicists and chemists to explore new avenues of investigation. Our transdisciplinary approach allows us to address important problems whose complex cause-and-effect relations cross over traditional disciplinary boundaries.
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Biochemistry
Cell Biology
Disease Biology
Tissue Microstructure
Biophotonics and Image Analysis
Biochemistry
Biochemistry
We investigate how the structure of macromolecules and the dynamic modulation of biochemical pathways contribute to health and disease. Because the subjects of our analysis range from single molecules to cells and tissues, we are able to capture the full complexity of these metabolic processes. Some of our main areas of research include:
- the regulation of the tissue proteome
- the effects of the biochemical microenvironment on tissue structure and function
- the role of cellular metabolism in regulating cellular activation and function
TEAM Hub Core Research Members
Dr. William Willmore
Credentials:
PhD
Position:
Topic Lead Biochemistry
Research Area(s):
Biochemistry, Biophotonics and Image Analysis, Cell Biology
Institution:
Carleton University
Expertise:
Stress Response, Hypoxia, Oxidative Stress, Proteomics
Dr. Adam Shuhendler
Credentials:
PhD, CRC-T2 in Chemical Biology
Position:
Topic Lead Biophotonics and Image analysis
Research Area(s):
Biochemistry, Biophotonics and Image Analysis, Disease Biology
Institution:
University of Ottawa, University of Ottawa Heart Institute
Expertise:
Biochemistry of Disease, Molecular Therapeutics, Molecular Imaging Self-Assembly, MRI, PET
Dr. Edana Cassol
Credentials:
PhD
Position:
Co-director, Topic Lead Cell Biology
Research Area(s):
Biochemistry, Cell Biology, Disease Biology
Institution:
Carleton University, Bruyere Research Institute
Expertise:
Macrophages, Host-Pathogen Interactions, Immunometabolism, Systems Biology
Recent Publications
Publication
Targeting mRNA binding proteins to respond to stress responses
The paper establishes the phosphorylation of heterogeneous nuclear ribonucleoprotein A1…
Publication
Using nanoparticles to respond to cellular stress responses
This is a review on the effects on nanoparticles (NPs), which are increasingly used in a…
Cell Biology
Cell Biology
We study how specific cell populations contribute to tissue homeostasis, damage, and disease, and how the tissue microbiome affects these processes. In particular, we evaluate tissue-specific features of cellular phenotype and function across health and disease, exploring subjects including:
- the dynamic reciprocation between cells and ECM
- the ways cellular interactions maintain tissue homeostasis
- the regulation of tissue remodelling as mediated by the microbiome
TEAM Hub Core Research Members
Dr. Edana Cassol
Credentials:
PhD
Position:
Co-director, Topic Lead Cell Biology
Research Area(s):
Biochemistry, Cell Biology, Disease Biology
Institution:
Carleton University, Bruyere Research Institute
Expertise:
Macrophages, Host-Pathogen Interactions, Immunometabolism, Systems Biology
Dr. Joerg Overhage
Credentials:
PhD
Position:
Topic Lead Cell Biology
Research Area(s):
Cell Biology, Disease Biology
Institution:
Carleton University
Expertise:
Biofilms, Microbiome, Antimicrobials, Antimicrobial Resistance
Dr. Menno Oudhoff
Credentials:
PhD
Position:
Topic Lead Disease Biology
Research Area(s):
Cell Biology, Disease Biology
Institution:
Carleton University
Expertise:
Mucosal Immunology and Epithelial (Stem Cell) Biology
Dr. William Willmore
Credentials:
PhD
Position:
Topic Lead Biochemistry
Research Area(s):
Biochemistry, Biophotonics and Image Analysis, Cell Biology
Institution:
Carleton University
Expertise:
Stress Response, Hypoxia, Oxidative Stress, Proteomics
Recent Publications
Publication
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia
Although Helminth infections are prevalent throughout the world, they are particular a health…
Publication
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
After birth, the epithelium that lines our gut transitions (or matures) so that it can deal…
Disease Biology
Disease Biology
We investigate how such factors as ageing, injury, environmental factors, and disease affect tissue remodelling and lead to damage and eventual loss of organ function. Our analysis includes the examination of tissue-specific features of disease across clinical cohorts in relation to:
- chronic lung disease
- cancer
- cardiovascular disease
- chronic wounds
TEAM Hub Core Research Members
Dr. Barbara Vanderhyden
Credentials:
PhD
Position:
Topic Lead Disease Biology
Research Area(s):
Disease Biology, Tissue Microstructure
Institution:
Ottawa Hospital Research Institute, University of Ottawa
Expertise:
Cancer; Infertility; Ovarian cancer; Women’s health
Dr. Emilio I. Alarcón
Credentials:
PhD
Position:
Topic Lead Disease Biology
Research Area(s):
Biophotonics and Image Analysis, Disease Biology, Tissue Microstructure
Institution:
University of Ottawa, University of Ottawa Heart Institute
Expertise:
3D Bioprinting and Biomedical Devices, for Regenerative Therapies
Dr. Adam Shuhendler
Credentials:
PhD, CRC-T2 in Chemical Biology
Position:
Topic Lead Biophotonics and Image analysis
Research Area(s):
Biochemistry, Biophotonics and Image Analysis, Disease Biology
Institution:
University of Ottawa, University of Ottawa Heart Institute
Expertise:
Biochemistry of Disease, Molecular Therapeutics, Molecular Imaging Self-Assembly, MRI, PET
Dr. Edana Cassol
Credentials:
PhD
Position:
Co-director, Topic Lead Cell Biology
Research Area(s):
Biochemistry, Cell Biology, Disease Biology
Institution:
Carleton University, Bruyere Research Institute
Expertise:
Macrophages, Host-Pathogen Interactions, Immunometabolism, Systems Biology
Dr. Joerg Overhage
Credentials:
PhD
Position:
Topic Lead Cell Biology
Research Area(s):
Cell Biology, Disease Biology
Institution:
Carleton University
Expertise:
Biofilms, Microbiome, Antimicrobials, Antimicrobial Resistance
Dr. Leila Mostaço-Guidolin
Credentials:
PhD, PEng
Position:
Co-director, Topic Lead Tissue Microstructure
Research Area(s):
Biophotonics and Image Analysis, Disease Biology, Tissue Microstructure
Institution:
Carleton University
Expertise:
Microscopy, Imaging Analysis, Tissue Engineering
Recent Publications
Publication
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia
Although Helminth infections are prevalent throughout the world, they are particular a health…
Publication
Examination of effects of tumour microenvironment on WNT signaling
This paper examines the response of the WNT signaling pathway involved in the development…
Tissue Microstructure
Tissue Microstructure
We combine tissue engineering and biomaterials to explore different applications that are crucial to regenerative medicine. These involve methods and components aimed at repairing/replacing body functions that have been lost or impaired due to disease, injury, or other conditions. Tissue engineering comprises a set of methods to produce living functional tissue from cell cultures that have been combined with structures that resemble living tissues as closely as possible. Biomaterials are fabricated materials developed for, and used in, products intended for medical treatments, including structures that will provide a foundation for artificial engineered tissues. Particular areas of TEAM Hub research include:
- cells’ conversion of mechanical stimuli into biochemical signals
- the emergence of tissue-scale mechanics from the formation of intercellular junctions
- the development of collagen-based biomaterials to address myocardial infraction and atherosclerotic plaque development
- 3D in vitro models to understand interactions between asthmatic fibroblasts-macrophages and changes in the ECM structure
- the creation of hollow-tube structures to mimic lung airways
TEAM Hub Core Research Members
Dr. Andrew Harris
Credentials:
PhD
Position:
Topic Lead Tissue Microstructure
Research Area(s):
Biophotonics and Image Analysis, Tissue Microstructure
Institution:
Carleton University
Expertise:
Cell and Tissue Mechanics, Optical Microscopy, Tissue Engineering
Dr. Leila Mostaço-Guidolin
Credentials:
PhD, PEng
Position:
Co-director, Topic Lead Tissue Microstructure
Research Area(s):
Biophotonics and Image Analysis, Disease Biology, Tissue Microstructure
Institution:
Carleton University
Expertise:
Microscopy, Imaging Analysis, Tissue Engineering
Dr. Barbara Vanderhyden
Credentials:
PhD
Position:
Topic Lead Disease Biology
Research Area(s):
Disease Biology, Tissue Microstructure
Institution:
Ottawa Hospital Research Institute, University of Ottawa
Expertise:
Cancer; Infertility; Ovarian cancer; Women’s health
Dr. Emilio I. Alarcón
Credentials:
PhD
Position:
Topic Lead Disease Biology
Research Area(s):
Biophotonics and Image Analysis, Disease Biology, Tissue Microstructure
Institution:
University of Ottawa, University of Ottawa Heart Institute
Expertise:
3D Bioprinting and Biomedical Devices, for Regenerative Therapies
Recent Publications
Publication
Holding together to share the load
Sustaining and generating mechanical forces is a normal part of life for the tissues in…
Publication
Visualizing scar tissue with optical microscopy: what is happening with collagen fibers?
The ability to respond to injury with tissue repair is a fundamental property of all multicellular…
Biophotonics and Image Analysis
Biophotonics and Image Analysis
Recognizing that “seeing is believing,” we work to employ and develop a variety of non-invasive, label-free imaging modalities to visualize biological activities. Imaging modalities with biochemical specificity and high spatial/temporal resolution allow us to investigate 3D structures of tissues and cells in real time. Imaging and related technological development is a central aspect of several research projects carried by the TEAM Hub, including those aimed at:
- identifying inflammatory and microbial biomarkers that are predictive of healing responses across complex clinical cohorts
- examining how the skin microbiome regulates macrophage and fibroblast activation and function in wound healing
- evaluating how high- and low-dose radiation energy deposited in cells and tissues affects corresponding biological responses including tissue remodelling
- using label-free nonlinear optical microscopy to assess the effects of collagen remodelling in cells and tissues
- examining how the tissue microenvironment drives cellular metabolism and regulates macrophage activation and function
- developing molecular imaging probes for mapping biomolecule activity in cancer, fibrosis, and concussion in vitro and in vivo
- developing a compact and portable Raman spectroscopy imaging system
TEAM Hub Core Research Members
Dr. Adam Shuhendler
Credentials:
PhD, CRC-T2 in Chemical Biology
Position:
Topic Lead Biophotonics and Image analysis
Research Area(s):
Biochemistry, Biophotonics and Image Analysis, Disease Biology
Institution:
University of Ottawa, University of Ottawa Heart Institute
Expertise:
Biochemistry of Disease, Molecular Therapeutics, Molecular Imaging Self-Assembly, MRI, PET
Dr. Sangeeta Murugkar
Credentials:
PhD
Position:
Topic Lead Biophotonics and Image analysis
Research Area(s):
Biophotonics and Image Analysis
Institution:
Carleton University
Expertise:
Raman Spectroscopy, Nonlinear Optical Imaging, SRS, CARS Microscopy
Dr. Andrew Harris
Credentials:
PhD
Position:
Topic Lead Tissue Microstructure
Research Area(s):
Biophotonics and Image Analysis, Tissue Microstructure
Institution:
Carleton University
Expertise:
Cell and Tissue Mechanics, Optical Microscopy, Tissue Engineering
Dr. Emilio I. Alarcón
Credentials:
PhD
Position:
Topic Lead Disease Biology
Research Area(s):
Biophotonics and Image Analysis, Disease Biology, Tissue Microstructure
Institution:
University of Ottawa, University of Ottawa Heart Institute
Expertise:
3D Bioprinting and Biomedical Devices, for Regenerative Therapies
Dr. Leila Mostaço-Guidolin
Credentials:
PhD, PEng
Position:
Co-director, Topic Lead Tissue Microstructure
Research Area(s):
Biophotonics and Image Analysis, Disease Biology, Tissue Microstructure
Institution:
Carleton University
Expertise:
Microscopy, Imaging Analysis, Tissue Engineering
Dr. William Willmore
Credentials:
PhD
Position:
Topic Lead Biochemistry
Research Area(s):
Biochemistry, Biophotonics and Image Analysis, Cell Biology
Institution:
Carleton University
Expertise:
Stress Response, Hypoxia, Oxidative Stress, Proteomics
Recent Publications
Publication
Holding together to share the load
Sustaining and generating mechanical forces is a normal part of life for the tissues in…
