Understanding
Tissue Structure
The TEAM Hub draws on different disciplines and perspectives to investigate the role of the tissue microenvironment in disease
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We need better tools
to identify changes in biological tissues associated with disease before there is a significant disruption of tissue structure and function. We also need to streamline the development and testing of new therapeutics that can prevent or reverse tissue damage in chronic incurable diseases. The TEAM Hub is constructing a biologically inspired pipeline to generate a dynamic picture of the tissue microenvironment. Combining imaging approaches and 3D artificial tissue models, we investigate the effects of tissue structure on cellular functions, the mechanisms underlying changes in tissues and healing processes, and the factors that affect the body’s response to injuries and diseases.
Core Research Members
The TEAM Hub is composed of experts from diverse areas, ranging from Health Sciences to Physics and from Engineering to Biology. Meet the team behind this ambitious research.
Dr. Leila Mostaço-Guidolin
PhD, PEng
Co-director, Topic Lead Tissue Microstructure
Dr. Edana Cassol
PhD
Co-director, Topic Lead Cell Biology
Dr. Adam Shuhendler
PhD, CRC-T2 in Chemical Biology
Topic Lead Biophotonics and Image analysis
Dr. Andrew Harris
PhD
Topic Lead Tissue Microstructure
Dr. Barbara Vanderhyden
PhD
Topic Lead Disease Biology
Dr. Emilio I. Alarcón
PhD
Topic Lead Disease Biology
Dr. Jeffrey Smith
PhD
Topic Lead Biochemistry
Dr. Joerg Overhage
PhD
Topic Lead Cell Biology
Dr. Sangeeta Murugkar
PhD
Topic Lead Biophotonics and Image analysis
Dr. William Willmore
PhD
Topic Lead Biochemistry
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Features-at-a-Glance
Research Areas
Check below for details about all research conducted within the TEAM Hub.
FACILITIES
TEAM Hub Research Nodes
Check below for details about all research conducted within the TEAM Hub.
The Next Generation Of Experts
By providing research opportunities and developing educational programs for the larger community, we are helping Ontario and, indeed, all of Canada build expertise in emerging but increasingly important areas of research.
Latest News & Publications
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BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia
Although Helminth infections are prevalent throughout the world, they are particular a health...
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LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
After birth, the epithelium that lines our gut transitions (or matures) so that it can deal...
Targeting mRNA binding proteins to respond to stress responses
The paper establishes the phosphorylation of heterogeneous nuclear ribonucleoprotein A1...
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