About Us
Bringing together state-of-the-art imaging approaches to develop and test new 3D tissue models.
We are developing a toolkit of new technologies (3D tissue models, label-free imaging approaches, novel image analysis methods) to make fundamental discoveries related to tissue biology and remodeling and to accelerate the translation of important discoveries into animal models and clinical settings. Our transdisciplinary approach creates a synergistic space where ideas from various perspectives converge productively.
Revolutionizing Our Understanding of Tissue Structure
The Team
We are a group of experts from different disciplines working together to tackle one of the biggest challenges of modern times: the characterization and recreation of tissue microenvironments.
Research
We seek answers to questions related to tissue homeostasis and disease. New technologies resulting from our work will facilitate diagnosis and treatment of many chronic diseases.
Infrastructure
Our state-of-the-art microscopy and analytical techniques allow us to analyze the complex biochemical and biophysical processes that occur in tissue microenvironments.
Training
By providing research opportunities and developing educational programs for the larger community, we are helping Ontario and, indeed, all of Canada build expertise in emerging but increasingly important areas of research, including tissue engineering and imaging.
Core Research Members
The TEAM Hub is composed of experts from diverse areas, ranging from Health Sciences to Physics and from Engineering to Biology. Meet the team behind this ambitious research.
Dr. Leila Mostaço-Guidolin
PhD, PEng
Co-director, Topic Lead Tissue Microstructure
Dr. Edana Cassol
PhD
Co-director, Topic Lead Cell Biology
Dr. Adam Shuhendler
PhD, CRC-T2 in Chemical Biology
Topic Lead Biophotonics and Image analysis
Dr. Andrew Harris
PhD
Topic Lead Tissue Microstructure
Dr. Barbara Vanderhyden
PhD
Topic Lead Disease Biology
Dr. Emilio I. Alarcón
PhD
Topic Lead Disease Biology
The Latest News & Publications
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia
Although Helminth infections are prevalent throughout the world, they are particular a health...
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
After birth, the epithelium that lines our gut transitions (or matures) so that it can deal...
Targeting mRNA binding proteins to respond to stress responses
The paper establishes the phosphorylation of heterogeneous nuclear ribonucleoprotein A1...