Targeting mRNA binding proteins to respond to stress responses

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Research Area: Biochemistry, Cell Biology

https://doi.org/10.1016/j.jbc.2022.102364

Authors: Krishna Bhattarai, Travis Richard, Thet Fatica, Brianna Frangione, William G. Willmore, Martin Holcik

DOI Link: https://doi.org/10.1016/j.jbc.2022.102364

The paper establishes the phosphorylation of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) by the AMPK-related protein kinase 5 (ARK5) in human bone osteosarcoma epithelial (U2OS) cells during hypertonic stress. Phosphorylation of hnRNP A1 by ARK5 causes it to move from the nucleus to the cytosol where it binds to specific mRNAs. The silencing of ARK5 increases the expression of antiapoptotic protein Bcl-xL and consequently delays caspase activation. hnRNP A1 is a mRNA-binding protein which controls various aspects of the cell stress response.

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