BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia

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Research Area: Cell Biology, Disease Biology

Authors: Håvard T. Lindholm, Naveen Parmar, Claire Drurey, Marta Campillo Poveda, Pia M. Vornewald, Jenny Ostrop, Alberto Díez-sanchez, Rick M. Maizelsand, Menno J. Oudhoff

Although Helminth infections are prevalent throughout the world, they are particular a health issue in developing countries. We still don’t fully know how immunity to helminth infections are mounted, nor how the strengths of such immune responses are tailored. We here find that specialized epithelial cells called tuft cells, are providing an epithelial-intrinsic feedback mechanism during helminth-induced immune responses. This is important so the body doesn’t ‘overreact’ during an infection, which is often a detrimental feature during infection or inflammation.

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